Our body has its own defense system, which protects us from diseases and consists of various components. One of them is the immune system, which actively advances the body against anything it considers foreign or harmful. The maximum defense against even the smallest foreign bodies is ensured by antibodies (immunoglobulins). Once activated, they accurately recognize foreign structures (such as a non-matching puzzle piece) and mark them for deactivation. Our body uses the antibodies of different classes to build up several defensive rings that act before entry into the body, immediately upon entry, and inside the body.
IgE is a special class of antibodies that recognize and prevent the entry of foreign and hostile substances into the body. It therefore triggers reactions that impede or block entry. This also explains the typical symptoms associated with IgE-binding, namely: heavy secretion (tears, diarrhea, vomiting), coughing, convulsions and local inflammation (redness, itching, temperature increase).
The antibody class IgG is active if these substances are already in the body and must be deactivated or killed as soon as possible. Our internal defense against pathogenic bacteria and viruses is essentially based on this class of antibodies. The IgG is divided into several subclasses. One of them, the specific IgG4, is the least abundant of the subclasses, therefore an increase should be considered.
The general rule: When antibodies of the IgG class bind to their target, a defense and inflammatory response is set in motion with the goal of blocking and destroying the structure recognized as foreign. The reactions are usually not as strongly felt as with IgE. If misguided, they can cause long-term damage and chronic discomfort.